DRUG-DRUG INTERACTIONS OF IRINOTECAN, 5-FLUOROURACIL, FOLINIC ACID AND OXALIPLATIN AND ITS ACTIVITY IN COLORECTAL CARCINOMA TREATMENT

Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment

The combination of folinic acid, 5-fluorouracil, oxaliplatin and/or irinotecan (FOLFOXIRI) is the standard of care for metastatic colorectal cancer (CRC).This strategy inhibits tumor growth but provokes drug resistance and serious side effects.We po boy fest 2023 aimed to improve FOLFOXIRI by optimization of the dosing and the sequence of drug admi

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Unicanvas: Exploring a tool for strategic management [version 2; peer review: 1 approved, 4 approved with reservations]

Purpose This research proposes an adapted version of Business Model Canvas (BMC) as a potential strategic tool for the design china glaze fairytale bliss of the business model of Higher Education Institutions (HEIs).In the context of fifth-generation universities, the University-Model Canvas (Unicanvas) offers a solution to some limitations of trad

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Public key searchable encryption scheme based on blockchain

Aiming at the trapdoor security problem of the public key encryption scheme,a random number constructing trapdoor and index was introduced to defend against keyword porky pig face guessing attacks from the server and avoid data leakage caused by server curious behavior.Research on trusted issues of third parties,the blockchain mechanism with a sear

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Uretero-pelvic junction obstruction in children: Is vascular hitch an effective and safe solutions in very long term outcome? Report of 25 years follow-up

Vascular (VH) according to Hellstrom-Chapman technique is considered a safe and effective alternative approach to pure extrinsic Ureteropelvic Junction Obstruction (UPJO) with good results in short and medium term, but few data are available on long and verylong term outcomes.Our aim is to evaluate VH long and very-long yazhi design saree term outc

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